OTIBONE PLUS

DOSAGE AND ADMINISTRATION

Dosage

Dosage should be individualized and adjusted according to the specific disease being treated, its severity, and the response of the patient.

Adults

First three weeks: 1 tablet x 2-3 times a day 

Consecutive days: 1-2 tablets one time per day. 

The duration of treatment is 3-6 months. 

If necessary, the treatment can be repeated and the duration of it is determined individually.

If side effects in relation to the digestive system appear, the dose of the drug should be reduced to 2 times. If there are no improvements, the administration of the drug should be canceled.

This product can be used in a combination therapy with Glasgow Coma Scale (GCS) and Non steroidal anti-inflammatory drugs (NSAIDs). 

Administration

Oral administration only, before eating, with plenty of water.

CONTRAINDICATIONS

This product is contraindicated in patients with:

+ Hypersensitivity to any drug components 

+ Thrombophlebitis 

+ Tendency to bleeding sickness

+ Pregnancy and lactation.

+ Taking coumarin anticoagulant especially warfarin. 

+ Allergy to shellfish as the active substance is obtained from shellfish.

WARNINGS AND PRECAUTIONS

It should be administered with caution by the patients with diabetes, since chondroitin sulfate has the effect of reducing the tolerance to insulin.

In patients with impaired glucose tolerance, monitoring of the blood glucose levels and, where relevant, insulin requirements is recommended before start of treatment and periodically during treatment. 

Exacerbation of asthma symptoms after initiation of glucosamine have been described (symptoms resolved after withdrawal of glucosamine), therefore, asthmatic patients starting on glucosamine should be aware of potential worsening of symptoms.

In patients with known risk factor for cardiovascular disease, monitoring of the blood lipid levels is recommended, since hypercholesterol.

Patients should stop taking OTIBONE PLUS at least 2 weeks before taking a surgery because of interaction of product with anticoagulants.

Chitosan can make chondroitin harder to be absorbed, patients should avoid taking chitosan while taking OTIBONE PLUS.

PREGNANCY AND LACTATION

OTIBONE PLUS is contraindicated during the pregnancy and lactation period.

EFFECTS ON ABILITY TO DRIVE AND USE MACHINES

OTIBONE PLUS doesn’t influence the ability to drive as well as to perform works requiring the heightened attention concentration.

STORAGE

In a dry place, below 30°C, protect from light.

SHELF-LIFE 

36 months from the manufacturing date.