Idofen 200

POSOLOGY AND METHOD OF ADMINISTRATION

Method of administration: Oral route

Posology:

Adults:

Mild to moderate pain

The usual dose for pain relief is 1.2 - 1.8 g/day, divided into several small doses, the maintenance dose of 0.6 - 1.2 g/day has been effective. If necessary, the dose can be increased, up to a maximum dose of 2.4 g/day or 3.2 g/day. The dose for rheumatoid arthritis is higher than the dose for osteoarthritis.

The recommended dose to reduce fever is 200 – 400 mg every 4 – 6 hours, up to a maximum of 1.2 g/day.

Children: The usual dose for pain or fever is 20 - 30 mg/kg/day, divided into several small doses, 6 – 8 times a day.

The maximum dose for juvenile rheumatoid arthritis is 40 mg/kg/day.

Do not use in children weighing less than 7 kg

A maximum daily dose of 500 mg for children weighing less than 30 kg is suggested.

The dosage of ibuprofen should be reduced in patients with impaired renal function. The safety of the drug in patients with renal failure has not been established.

CONTRAINDICATIONS

- Hypersensitivity to ibuprofen 

- Active peptic ulcer disease

- Hypersensitivity to aspirin or to NSAIDs (asthma, rhinitis, urticaria after using aspirin)

- Patient with asthma or bronchospasm, bleeding disorder, cardiovascular diseases,  history of peptic ulcer, hepatic failure or renal failure (creatinine clearance less than 30 ml/min)

- The patient is being treated with the coumarin anticoagulant

- Patients with congestive heart failure, decreased blood volume due to diuretics or renal failure (this drug increases the risk of kidney dysfunction)

- Patients with collagen vascular disease (these people are at risk of aseptic meningitis. It is important to note that all patients with aseptic meningitis have a history of autoimmune disease)

- Last 3 months of pregnancy.

PRECAUTION

Arterial thrombosis 

+ Non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) not aspirin is given by systemic route, can increase the risk of cardiovascular thrombotic events, including myocardial infarction and stroke, which can lead to death. This risk can appear in the first few weeks of taking the drug and may increase with the duration of taking the drug. The risk of arterial thrombosis was observed mainly at a high dose.

+ Physician should periodically evaluate the occurrence of cardiovascular events, even if the patient has no prior cardiovascular symptoms. Patients should be alerted to the symptoms of a serious cardiovascular event and seek medical attention as soon as these symptoms appear.

+ To reduce the risk of adverse events, ibuprofen should be used at the lowest effective daily dose for the shortest time.

+ Use with caution in the elderly

+ Ibuprofen may increase transaminases in the blood, but this change is transient and reversible.

Visual disturbances, such as blurred vision, are subjective and related to the adverse effects of the drug, but resolved with discontinuation of the drug.

+ Ibuprofen inhibits platelet aggregation and prolonged bleeding time

SHELF LIFE

36 months from the manufacturing date. Do not use this product after the expiry date.

Aluminum/PVC blister.

Box of 05 blisters x 10 film-coated tablets